
Pharmacological treatment
Pharmacological or drug treatment of COPD aims to relieve symptoms, reduce the frequency and severity of exacerbations and improve general health. It is essential to personalize each treatment plan, as the interaction between symptom severity, airway obstruction and exacerbation intensity varies from person to person.
1 Bronchodilators
They are often prescribed first for COPD sufferers. Bronchodilators relax the muscles around the airways so you can breathe more easily. They can be short-acting (for immediate relief) or long-acting (used regularly to control symptoms). Short-acting bronchodilator inhalers are generally the first choice for COPD sufferers.
There are two main types of bronchodilators used in the management of COPD:
- Short-acting beta2-agonists (SABAs): examples include salbutamol, phenoterol, terbutaline and levalbuterol. Used for rapid relief of acute symptoms. The effect generally lasts 4–6 hours.
- Long-acting beta2-agonists (LABAs): examples include salmeterol, formoterol, arformoterol, olodaterol and indacaterol. These drugs provide long-lasting bronchodilation (12 hours or more) and are used regularly to control symptoms.
2 Anticholinergics
- Short-acting anticholinergics (SAMAs): ipratropium and oxitropium are examples. Like SABAs, they are used for rapid relief of symptoms.
- Long-acting anticholinergics (LAMAs): examples include tiotropium, glycopyrronium, revefenacin, aclidinium and umeclidinium. LAMAs are used as maintenance therapy for long-term bronchodilation and symptom control.
Bronchodilators can be administered using a variety of devices, including inhalers or nebulizers. The choice depends on disease severity, individual preferences and your doctor's recommendations.
3 Inhaled corticosteroids
Reduce airway inflammation and help prevent flare-ups, which is particularly beneficial for people with frequent COPD flare-ups.
The efficacy of inhaled corticosteroids alone remains uncertain. However, combining them with long-acting bronchodilators appears more effective in improving lung function and reducing flare-ups than using each drug separately.
4 Mucolytics
Mucolytic drugs such as carbocisteine or acetylcysteine act by thinning the mucus in the bronchi, making it easier to clear by coughing. They help reduce flare-ups and hospital admissions for COPD sufferers.
5 Antibiotics
If there are signs of respiratory infection, the doctor may prescribe antibiotics to reduce the risk of exacerbation.
6 Possible questions to ask your doctor
- How long does it take for the effects of this medication to be felt?
- What are the possible side effects or risks associated with this medication?
- Are there any special precautions to take when using this medicine?
- How is it administered (orally, by injection, by infusion)?
- Are there any interactions with other medications or supplements I'm currently taking?
- How often should I have check-ups or monitoring appointments while taking this medication?
- What should I do if I experience side effects or adverse reactions?
- How long should I take this medicine?
- How does this drug fit into my overall COPD treatment plan?
- Are there any lifestyle changes or precautions I should take while on this medication?
- What should I do if I miss a dose?
